| Date | Location | Result | |
| Dec 11, 2021 | Huntsville, Texas | Montana State 42, Sam Houston 19 | Box score |
| Dec 04, 2021 | Huntsville, Texas | Sam Houston 49, UIW 42 | Box score |
| Nov 20, 2021 | Abilene, Texas | Sam Houston 35, Abilene Christian 9 | Box score |
| Nov 13, 2021 | Huntsville, Texas | Sam Houston 42, Eastern Kentucky 28 | Box score |
| Nov 06, 2021 | Huntsville, Texas | Sam Houston 59, Dixie State 10 | Box score |
| Oct 30, 2021 | Stephenville, Texas | Sam Houston 45, Tarleton 27 | Box score |
| Oct 23, 2021 | Huntsville, Texas | Sam Houston 42, Jacksonville State 7 | Box score |
| Oct 09, 2021 | Huntsville, Texas | Sam Houston 41, Lamar 7 | Box score |
| Oct 02, 2021 | Houston, Texas | Sam Houston 21, Stephen F. Austin 20 | Box score |
| Sep 25, 2021 | Conway, Ark. | Sam Houston 45, Central Arkansas 35 | Box score |
| Sep 11, 2021 | Huntsville, Texas | Sam Houston 52, Southeast Missouri 14 | Box score |
| Sep 02, 2021 | Flagstaff, Ariz. | Sam Houston 42, Northern Arizona 16 | Box score |